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KMID : 0383820100680060345
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Tuberculosis and Respiratory Diseases
2010 Volume.68 No. 6 p.345 ~ p.349
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Significance of Repeated Polymerase Chain Reaction (PCR) Testing for Diagnosis of Pulmonary Tuberculosis
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Kim Soo-Ok
Oh In-Jae
Kim Kyu-Sik
Kim Yu-Il
Lim Sung-Chul
Kim Young-Chul
Chi Su-Young
Kwon Yong-Soo
Kim Yoon-Hee
Ban Hee-Jung
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Abstract
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Background: The polymerase chain reaction (PCR) test is important for the confirmatory diagnosis of tuberculosis (TB) caused by Mycobacterium tuberculosis. The aim of this study was to analyze the yield of repeated PCR testing in patients with confirmed pulmonary TB.
Materials and Methods: The medical records of 130 patients, who had more than two consecutive PCR tests and a M. tuberculosis- positive sputum culture from August, 2006 to December, 2007, were retrospectively reviewed for the purposes of this study. A positive TB-PCR test was defined as at least one positive test result.
Results: The cumulative positive PCR test rate was 80% (104/130), with gradually increasing rates of positive findings upon the first, second and third TB-PCR tests with 52.3%, 68.5% and 75.4%, respectively. However, further testing did not increase the positive rate further.
Conclusion: Repeated PCR testing at least three times for M. tuberculosis is helpful for diagnosis of pulmonary TB.
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KEYWORD
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Polymerase Chain Reaction, Tuberculosis, Sputum
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